Wednesday, September 05, 2007

Wiring : An Interlude - DBS TIFR AWS On Adult Neurogenesis

Epigenetic mechanisms speculated in neurological stress response in maternal separation paradigm of mice neurobiology model.

This one hit me like a bullet. Shaken.

3 comments:

about:blank said...

From the abstract of Weaver et al Aug 2004, Nat. Neuro. Vol 7 No.8

"Here we report that increased pup licking and grooming (LG) and arched-back nursing (ABN) by rat mothers altered the offspring
epigenome at a glucocorticoid receptor (GR) gene promoter in the hippocampus....
.......we show that an epigenomic state of a gene can be established
through behavioral programming, and it is potentially reversible."

It is a nice enough paper in terms of experiments...but what it says about the role of epigenetics in behavior is the more interesting thing about this paper :)

Pushkar said...

crazy stuff isn't it!

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